Plasma lipids define the longevity of mammals. This is the main conclusion of a study performed by researchers from Lleida University (UdL), belonging to the research group Metabolic Physiopathology of IRBLleida, lidered by Dr. Reinald Pamplona. The study has been performed on 11 mammal species and has been published in Scientific Reports a primary research publication from the publishers of Nature, online and open access.
According to the results of the study, the longer the longevity of a species, the lower is its plasma long-chain free fatty acid (with more than 12 carbons). Their lipids are also more resistant to oxidation, a process that contributes to cellular ageing.
Researchers have used high-throughput technologies to determine the plasma lipidomic profile of mouse, rat, rabbit, guinea-pig, cat, dog, pig, horse, sheep, bull and man. This approach revealed a specie-specific lipidomic profile that accurately predicts the animal longevity. The next step in this research will be to study plama from different individuals from the same species to decipher why some of the live longer than others. The team directed by Dr. Reinald Pamplona has started a project in collaboration with researchers from Valencia University on plasma lipidomic profile in humans older than 100.
Researchers from Complutense University and Malaga University participated in the research published in Scientific Reports.