The International Psoriasis Council (IPC) has chosen an article published by the translational research group on immunodermatology led by Luis Francisco Santamaria from the Faculty of Biology of the University of Barcelona and the Barcelona Science Park, as one of the best of 2013 about psoriasis. Psoriasis is a chronic cutaneous inflammatory disease of the skin that is highly prevalent and significantly affects the quality of life of patients. Last year a total of 1,908 papers on the disease were published, according to data obtained from the portal PubMed.
One of the main conclusions of the article, published in the Journal of Investigative Dermatology, is that Streptococcus pyogenes antigens are directly involved in the pathological mechanisms that result in the appearance of psoriasis lesions. According to Dr. Santamaria, “although many research studies have been focused on psoriasis, immunopathogenic mechanisms are essential but remain hardly known”. He adds that ” the particularity of the study is that it establishes a new ex-vivo model to elucidate how psoriasis lesions are initiated and triggered by means of the interaction among the bacterium Streptococcus pyogenes, CLA+ T lymphocytes (a group of circulating cells which play a major role in psoriasis physiopathology), and epidermal cells”.